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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Maria Kowalczuk
Welcome to BMC Bioinformatics published by BioMed Central
BMC Bioinformatics is an open access journal publishing original peer-reviewed research articles in all aspects of computational methods used in the analysis and annotation of sequences and structures, as well as all other areas of computational biology.
BMC Bioinformatics (ISSN 1471-2105) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Thomson Reuters (ISI) and Google Scholar.
Featured articles
BMC Bioinformatics 2008, 9 :353
The MisPred tool improves gene predictions within public databases by using five distinct approaches to detect incomplete or incorrect sequences, such as missing signal peptides or problems with domain integrity.
BMC Bioinformatics 2008, 9 :303
A generalized algorithm that simultaneously estimates both local false discovery rates and tail area-based FDR gives a common framework to apply a range of test statistics to high-dimensional data.
BMC Bioinformatics 2008, 9 :301
More accurate topologies of protein-protein interaction networks can be deduced by building core sub-networks using filtered information from experimental data sets.
BMC Bioinformatics 2008, 9 :292
The effect of genetic pathways on disease outcome can be estimated by combining both parametric and non-parametric modeling using kernel machines, a framework that includes nonlinear effects and interactions between genes within a single pathway.
BMC Bioinformatics 2008, 9 :286
By comparing an organism's chromosomes to those of closely related species using a segmentation algorithm, breakpoints can be precisely delimited and their internal structure described, providing insights into the mechanisms and evolutionary properties of chromosomal rearrangements.
Volume 9 Suppl 9
Proceedings
Oklahoma City, OK, USA. 23 Volume 9 Suppl 8
Proceedings
Evry, France. 25 Volume 9 Suppl 7
Meeting abstracts
Cadiz, KY, USA. 28
more info ]
Methodology article
Prediction of beta-turns at over 80% accuracy based on an ensemble of predicted secondary structures and multiple alignments Ce Zheng, Lukasz Kurgan BMC Bioinformatics 2008, 9 :430 (10 [Abstract ] [Provisional PDF ]
Research article
Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure Christopher Bystroff, Bobbie-Jo Webb-Robertson BMC Bioinformatics 2008, 9 :429 (10 [Abstract ] [Provisional PDF ]
Software
SPSmart: adapting population based SNP genotype databases for fast and comprehensive web access Jorge Amigo, Antonio Salas, Christopher Phillips, Angel Carracedo BMC Bioinformatics 2008, 9 :428 (10 [Abstract ] [Provisional PDF ]
Research article
Homology modelling of protein-protein complexes: a simple method and its possibilities and limitations Guillaume Launay, Thomas Simonson BMC Bioinformatics 2008, 9 :427 (9 [Abstract ] [Provisional PDF ]
Research article
Mining protein networks for synthetic genetic interactions Sri R Paladugu, Shan Zhao, Animesh Ray, Alpan Raval BMC Bioinformatics 2008, 9 :426 (9 [Abstract ] [Provisional PDF ]
Research article
Discovery of Dominant and Dormant Genes from Expression Data
Using a Novel Generalization of SNR for Multi-class Problems Yu-Shuen Tsai, Chin-Teng Lin, George C. Tseng, I-Fang Chung, Nikhil R. Pal BMC Bioinformatics 2008, 9 :425 (9 [Abstract ] [Provisional PDF ]
Research article
Detection of the dominant direction of
information flow and feedback links
in densely interconnected regulatory networks Iaroslav Ispolatov, Sergei Maslov BMC Bioinformatics 2008, 9 :424 (8 [Abstract ] [Provisional PDF ]
Software
LC-MSsim - a simulation software for Liquid Chromatography
Mass Spectrometry data Ole Schulz-Trieglaff, Nico Pfeifer, Clemens Gropl, Oliver Kohlbacher, Knut Reinert BMC Bioinformatics 2008, 9 :423 (8 [Abstract ] [Provisional PDF ]
Software
SIGMA2: A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes Raj Chari, Bradley P Coe, Craig Wedseltoft, Marie Benetti, Ian M Wilson, Emily A Vucic, Calum MacAulay, Raymond T Ng, Wan L Lam BMC Bioinformatics 2008, 9 :422 (7 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Bayesian modeling of recombination events in bacterial populations Pekka Marttinen, Adam Baldwin, William P Hanage, Chris Dowson, Eshwar Mahenthiralingam, Jukka Corander BMC Bioinformatics 2008, 9 :421 (7 [Abstract ] [Provisional PDF ]
Research article
Unique genes in plants: specificities and conserved features throughout evolution David Armisen, Alain Lecharny, Sebastien Aubourg BMC Evolutionary Biology 2008, 8 :280 (10 [Abstract ] [Provisional PDF ]
Database
Pepper EST database: comprehensive in silico tool for analyzing the chili pepper (Capsicum annuum) transcriptome Hyun-Jin Kim, Kwang-Hyun Baek, Seung-Won Lee, JungEun Kim, Bong-Woo Lee, Hye-Sun Cho, Woo Taek Kim, Doil Choi, Cheol-Goo Hur BMC Plant Biology 2008, 8 :101 (9 [Abstract ] [Provisional PDF ]
Research article
Quantifying information transfer by protein domains: Analysis of the Fyn SH2 domain structure Tom Lenaerts, Jesper Ferkinghoff-Borg, Francois Stricher, Luis Serrano, Joost Schymkowitz, Frederic Rousseau BMC Structural Biology 2008, 8 :43 (8 [Abstract ] [Provisional PDF ]
Research article
Retrocopy contributions to the evolution of the human genome. Robert Baertsch, Mark Diekhans, W. James Kent, David Haussler, Juergen Brosius BMC Genomics 2008, 9 :466 (8 [Abstract ] [Provisional PDF ]
Research article
Relationships of Gag-pol Diversity between Ty3/Gypsy and Retroviridae LTR retroelements and the three kings hypothesis Carlos Llorens, Mario A Fares, Andres Moya BMC Evolutionary Biology 2008, 8 :276 (8 [Abstract ] [Provisional PDF ]
Research article
Prediction of evolutionarily conserved interologs in Mus musculus Sailu Yellaboina, Dawood B Dudekula, Minoru SH Ko BMC Genomics 2008, 9 :465 (8 [Abstract ] [Provisional PDF ]
Discovery notes
Transduplication resulted in the incorporation of two protein-coding sequences into the Turmoil-1 transposable element of C. elegans Noa Sela, Adi Stern, Wojciech Makalowski, Tal Pupko, Gil Ast Biology Direct 2008, 3 :41 (8 [Abstract ] [Provisional PDF ]
Research article
Preferred and avoided codon pairs in three domains of life Age Tats, Tanel Tenson, Maido Remm BMC Genomics 2008, 9 :463 (8 [Abstract ] [Provisional PDF ]
Software
Tools for simulating evolution of aligned genomic regions with integrated parameter estimation Avinash Varadarajan, Robert K Bradley, Ian H Holmes Genome Biology 2008, 9 :R147 (8 [Abstract ] [Provisional PDF ]
Database
DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions Jingkai Yu, Svetlana Pacifico, Guozhen Liu, Russell L. Finley Jr. BMC Genomics 2008, 9 :461 (7 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Featured articles 
24 February 2008
