In response to environmental and other experimental perturbations, the Arabidopsis transcriptome shows 998 regulons of co-expressed genes, corresponding to many known biological processes but also including many unannotated genes.

A reliable predictor for ovarian cancer progression based on microarray analysis of methylation changes reveals that Alu and satellite repeats are hypomethylated whereas promoter CpG islands are hypermethylated with more advanced disease.

Overexpression of the regulatory subunit of cAMP-dependent protein kinase (PKA) in ovarian cancer cells causes hyperproliferation for the RI isoform and differentiation for RII, suggesting that PKA may be pivotal in disease progression.

A reductase enzyme in the mevalonate pathway is associated with prolonged recurrence free survival in ER positive breast cancer, but may have an inverse relationship with prognosis in ER negative tumors.

A new algorithm, which mines databases of tissue specificity, gene connectivity and disease association, has identified a new group of genes that interact with disease causing genes and impact on disease outcomes.