This Collection focuses on the rapidly evolving field of epigenetics, emphasizing the intricate mechanisms regulating gene expression beyond the DNA sequence. The collection aims to highlight cutting-edge research and reviews that advance our understanding of epigenetic modifications and their implications in health, disease, and development. We seek contributions that explore the interplay between epigenetic changes and environmental factors, as well as those that delve into the latest technological advancements in the study of the epigenome.
Possible Topics to Include:
• Mechanisms of Epigenetic Regulation: DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs.
• Technological Innovations: Advances in ATAC-seq, ChIP-seq, and other high-throughput techniques.
• Multiomics Approaches: Integrating genomics, transcriptomics, proteomics, and metabolomics to understand epigenetic landscapes.
• Epigenetic Regulation in Development and Differentiation: Role in stem cells, differentiation pathways, and tissue-specific gene expression.
• Epigenetics in Disease: Epigenetic dysregulation in cancer, neurodegenerative disorders, metabolic diseases, and more.
• Environmental Epigenetics: How environmental factors such as diet, toxins, and stress influence the epigenome.
• Transgenerational Epigenetic Inheritance: Mechanisms and examples of epigenetic marks passed across generations.
• Therapeutic Approaches: Epigenetic drugs and potential therapeutic interventions targeting epigenetic modifications.
• Epigenetic Biomarkers: Identification and application in disease diagnosis and prognosis.
This collection welcomes both original research articles and comprehensive reviews. Authors are encouraged to submit work that provides new insights into epigenetic mechanisms, methodologies, or applications while exploring the broad implications of their findings. It aims to foster interdisciplinary dialogue and collaboration, shedding light on the complex and dynamic nature of the epigenome.