The thematic series focusses on two groups of antidiabetic medications that have demonstrated cardiovascular benefits with consistently reduced major adverse cardiac events, improvement in heart failure and diminished cardiovascular and all-cause mortality. Namely, these are the sodium-glucose cotransporter-2 inhibitors (SGLT2i, also called gliflozins) and the glucagon-like peptide-1 receptor agonists (GLP-1a, also called incretin mimetics).
Due to their cardioprotective effect, these compounds, as well as the GLP-1a "cousin" tirzepatide, represent a real breakthrough in antidiabetic therapeutics. Repurposing antidiabetic drugs for the treatment of cardiovascular diseases is a trend that may increase in a near future allowing the inclusion of new drugs when their underlying molecular mechanisms of action will be unveiled.
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